The s allele of 5-HTTLPR: a possible common link in the background of endophenotypes related to suicidal behaviours?
نویسندگان
چکیده
The s allele of 5-HTTLPR: a possible common link in the background of endophenotypes related to suicidal behaviours? Xenia Gonda, Konstantinos Fountoulakis, Jaanus Harro, Maurizio Pompili, Gyorgy Bagdy, Kareen K Akiskal, Hagop S Akiskal, Zoltan Rihmer From 1 International Congress on Neurobiology and Clinical Psychopharmacology and European Psychiatric Association Conference on Treatment Guidance Thessaloniki, Greece. 19-22 November 2009
منابع مشابه
Possible Association between Serotonin Transporter Gene Polymorphism and Suicide Behavior in Major Depressive Disorder
OBJECTIVE The serotonin transporter (5-HTT) genes are major candidate genes for modulating the suicidal behavior. We investigated the association between serotonin transporter polymorphisms and suicidal behavior in patients with major depressive disorder (MDD). METHODS Serotonin transporter intron 2 VNTR polymorphism (5-HTTVNTR) and serotonin transporter linked polymorphic region polymorphism...
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Mounting evidence supports the association between a polymorphism in the serotonin transporter gene promoter region (5-HTTLPR) and suicidal behaviour. Recently, a novel variant of the 5-HTTLPR L allele was identified. The previously unknown L(G) allele produced similar levels of gene expression to the S allele and might have been misclassified as a "high-expression" allele in previous associati...
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Background: Literature reports a genetic component for suicidal behavior, especially of determinant/violent type. One of the candidates has been the polymorphism 5-HTTLPR in the serotonin promoter. Employing a between group design, we wished to test the association between suicidal behavior and serotonin-related polymorphisms. Method: 350 Danish patients with average 14 years’ duration of illne...
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BACKGROUND Genes involved in the serotonin system are major candidates in association studies of suicidal behavior. In this case-control study we investigated whether the serotonin transporter (5-HTT) gene encoding the protein responsible for the reuptake of serotonin from the synapse after its release from serotonergic neurons is a susceptibility factor for suicidal behavior. METHODS A funct...
متن کاملSerotonin transporter gene may be involved in short-term risk of subsequent suicide attempts.
BACKGROUND In the first year following a suicide attempt, patients are at high risk for reattempt and for completed suicide. We aim to determine the predictive value of two serotonin-related genes, the tryptophan hydroxylase (TPH) and serotonin transporter (5-HTTLPR) genes that have been involved in the susceptibility to suicidal behavior. METHODS After a one-year follow-up study of 103 patie...
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عنوان ژورنال:
دوره 9 شماره
صفحات -
تاریخ انتشار 2010